Evaluation of Hepatic Iron Concentrations by R2* Magnetic Resonance Imaging in 35 Patients with Iron Overload: Comparison of R2* Measurements at 1.5T and 3T and Validation with Liver Biopsies
نویسندگان
چکیده
C. M. Hillenbrand, R. B. Loeffler, M. McCarville, R. Song, E. Hansbury, M. Rieman, N. Mortier, M. P. Smeltzer, C-S. Li, F. Hoffer, L. Kun, R. Ware, and J. Hankins Radiological Sciences, St. Jude Children’s Research Hospital, Memphis, TN, United States, Hematology, St. Jude Children’s Research Hospital, Memphis, TN, United States, Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN, United States
منابع مشابه
Assessment of Organ Specific Iron Overload in Transfusion-dependent Thalassemia by Magnetic Resonance Imaging Techniques
The consequence of repeated blood transfusions in thalassemia is iron overload in different organs. Magnetic resonance imaging (MRI) is a reliable, non-invasive and accurate method for iron detection in various tissues, hence the introduction of MRI has revolutionized the management of these patients and improved the life expectancy of them. Cardiac MRI T2* has a profound effect not only on est...
متن کاملCardiac and Hepatic T2*-Weighted Magnetic Resonance Imaging
Abstract Background Iron overload is the main transfusion related side effects in patients with transfusion dependent hemoglobinopathies. Severe iron deposition in tissues leads to organ dysfunction. Many organs can be affected such as heart, liver, and endocrine organs. Cardiac failure and liver fibrosis are the consequent of Iron overload in transfusion dependent hemoglobinopathy. Magne...
متن کاملAssessment of Pancreatic Iron Overload in Transfusion Dependent Thalassemic Patients
Advances in the management of transfusion dependent thalassemic patients have improved the survival of these patients. The most important consequence of repeated and frequent transfusions is iron accumulation in vital organs. The magnetic resonance imaging (MRI) is a non-invasive and valid technique for the estimation of iron stores. Despite multiple studies about cardiac and liver MRI T2*, the...
متن کاملR2* magnetic resonance imaging of the liver in patients with iron overload.
R2* magnetic resonance imaging (R2*-MRI) can quantify hepatic iron content (HIC) by noninvasive means but is not fully investigated. Patients with iron overload completed 1.5T R2*-MRI examination and liver biopsy within 30 days. Forty-three patients (sickle cell anemia, n = 32; beta-thalassemia major, n = 6; and bone marrow failure, n = 5) were analyzed: median age, 14 years, median transfusion...
متن کاملAssessment of iron deposition in the heart in sickle cell patients using 3.0 Tesla cardiovascular magnetic resonance
This study investigates the role of 3.0T R2* imaging for measuring cardiac iron overload. Experiments were conducted on calibrated phantoms and sickle cell disease (SCD) patients. R2* imaging at 3.0T enabled assessment of wide range of iron concentrations. R2* values at 3.0T were about double of those at 1.5T. Myocardial R2* showed weak and strong correlations with hepatic R2* and serum ferriti...
متن کامل